ArticleFrontiers in microbiology2025
A high effective expression of human D-glucuronyl C5-epimerase with dimer structure in
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Engineering genetic elements for microbial protein expression systems: Advances, challenges, applications, and prospects.Synthetic and systems biotechnology · 2026Review
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Abstract
Introduction: Heparan sulfate (HS), a linear anionic polysaccharide, participates in many physiological processes and exhibits many pharmacological activities. D-glucuronyl C5-epimerase (Glce) is one of the key enzymes in the biosynthesis of heparan sulfate proteoglycans. However, the recombinant Glce protein exhibits reduced catalytic activity and production yield, which substantially impedes the development of enzymatic methods for producing pharmaceutical-grade heparin. Methods: In this experiment, we established a valid method for heterologous expression in Escherichia coli ( Results: In the present study, we successfully overexpressed and purified human Glce Discussion: In summary, this study successfully overexpressed and purified human Glce protein in
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