Evidence map›Paper›PMID 40822354›Full record

ArticleiScience2025

Cholinotrophic basal forebrain connectome dysfunction in Down syndrome with and without dementia.

Marta Moreno-Rodriguez, Sylvia E Perez, Muhammad Nadeem, Elizabeth Head, Elliott J Mufson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marta Moreno-RodriguezDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Sylvia E PerezDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Muhammad NadeemDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, CA 92617, USA.
Elliott J MufsonDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholinotrophic basal forebrain (CTBF) neurons depend upon the complex interaction of both upstream and downstream nerve growth factor (NGF) signaling pathways for survival and function. Although dysfunction of the NGF system occurs in both Down syndrome (DS), not all individuals with DS develop dementia. Whether NGF system dysregulation differs between demented individuals with DS (DSD+) versus those without dementia (DSD-) is unknown. Here, we report a significant reduction in neurons positive for the p75

Indexed as

Cell biologyNeuroscience

Identifiers

PMID40822354
PMCPMC12357115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.