ArticleMedical journal, Armed Forces India2025
Incidental multifocal pancreatic neuroendocrine tumors: A rare synchronous conundrum with intra-ampullary and peri-ampullary adenocarcinoma.
Article in Medical journal, Armed Forces India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a rare case of synchronous multifocal pancreatic neuroendocrine tumors (pNETs) discovered incidentally during histopathological examination of a pancreatic adenocarcinoma. A 65-year-old female patient with right upper abdominal pain, jaundice, and weight loss was diagnosed with a periampullary adenocarcinoma. Imaging revealed a soft tissue lesion in the periampullary region, and a Whipple procedure was performed. Histological examination identified a moderately differentiated pancreaticobiliary adenocarcinoma and multiple foci of well-differentiated neuroendocrine tumors (NETs). Immunohistochemistry confirmed distinct tumor types, with adenocarcinoma showing CK7 positivity and NET positive for synaptophysin, chromogranin, and low Ki-67. This case highlights the diagnostic challenge of synchronous malignancies and underscores the importance of thorough histopathologic evaluation.
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