Evidence map›Paper›PMID 40821957›Full record

ArticlemicroPublication biology2025

Yeast pre-rRNA is processed at the A' site.

Laura M Dutca, Emily F Freed, Susan J Baserga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura M DutcaMolecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, Iowa City VA Health Care System, Iowa City, Iowa, United States.
Emily F FreedGenetics, Yale School of Medicine, New Haven, Connecticut, Dept. of Physics, Colorado School of Mines, Golden, Colorado, United States.
Susan J BasergaMolecular Biophysics & Biochemistry, Genetics and Therapeutic Radiology, Yale University and the Yale School of Medicine, New Haven, Connecticut, United States.

Funding

Novel regulatory networks driving human ribosome biogenesisR35GM131687 · NIGMS · YALE UNIVERSITY · PI Susan J Baserga · 2019 to 2026
$5.1M
NIGMS NIH HHS R35 GM131687
6 · The paper itself

Abstract

Maturation of the pre-ribosomal RNA (pre-rRNA) in eukaryotes involves a series of processing steps that remove transcribed spacer sequences to produce mature ribosomes. In many organisms two processing sites are located in the 5'external transcribed spacer (5'ETS), along with the site that defines the 5'-end of the 18S rRNA. However, the pre-rRNA processing site near the start site of transcription, known as A', has long been believed to be absent in the single-celled yeast,

Identifiers

PMID40821957
PMCPMC12355656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.