Evidence map›Paper›PMID 40821949›Full record

ArticleJournal of neurolinguistics2023

Word Picture Verification Performance Reveals Auditory Comprehension Deficits in Primary Progressive Aphasia.

Samuel Suh, Elizabeth DeLuque, Catherine Kelly, Xander Lee, Rachel Fabian Mace, Kristina Ruch, Massoud Sharif, Melissa D Stockbridge, Emilia Vitti, Donna C Tippett

Abstract read
In one paragraph

Article in Journal of neurolinguistics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Speech perception and language comprehension in primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel SuhDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Elizabeth DeLuqueDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Catherine KellyDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Xander LeeDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Rachel Fabian MaceDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Kristina RuchDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Massoud SharifDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Melissa D StockbridgeDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Emilia VittiDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.
Donna C TippettDepartment of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
The Neural Basis of Impaired Affective Prosody in Alzheimer's Disease and Frontotemporal DegenerationR01DC015466 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2017 to 2021
$3.5M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC011317NIDCD NIH HHS R01 DC015466
6 · The paper itself

Abstract

Word/picture verification has been found to be a sensitive measure of lexical-semantic abilities in post-stroke aphasia and reveals information about disruptions in semantic and phonological processing. Exploration of the nature of auditory comprehension deficits using word/picture verification has not been replicated in primary progressive aphasia (PPA). We tested 108 individuals with PPA [logopenic variant PPA (lvPPA), n = 50; nonfluent agrammatic PPA (nfaPPA), n = 36; semantic variant PPA (svPPA), n = 22] on a spoken word/picture verification task and a spoken word/picture matching task. The spoken word/picture matching task identified 22 (20%) of individuals as impaired, whereas the spoken word/picture verification task identified 51 (47%) of individuals as impaired (two-tailed p < 0.001). Errors on spoken word/picture verification were due to semantic rather than phonologic foils in lvPPA (nouns, p < 0.001; verbs, p < 0.001), svPPA (nouns, p < 0.001; verbs, p < 0.001), and for nouns (p = 0.001) but not verbs in nfaPPA. Spoken word/picture verification was a more sensitive measure of single-word auditory comprehension deficits in PPA than word/picture matching. The error pattern, consistent with the distributed model of semantic knowledge, suggests that degradation of semantic representations for both nouns and verbs can occur in lvPPA, which may help to distinguish lvPPA versus nfaPPA and guide treatment for anomia.

Indexed as

auditory comprehensionphonologicprimary progressive aphasiasemantic

Identifiers

PMID40821949
PMCPMC12356279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.