ReviewFrontiers in physiology2025
Dual role of lactate in human health and disease.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulation and clinical manifestations of gluconeogenesis dysfunction.npj metabolic health and disease · 2026Review
- Article
- Succinate and lactate produced as conserved biomarkers through chronic and transient substrate-level phosphorylation: from microorganisms to cancer.Journal of bioenergetics and biomembranes · 2026Review
- Data Resources and Computational Methods for Lactylation Site Prediction: A Mini-Review.International journal of molecular sciences · 2026Review
- Role and clinical importance of lactylation in tumors (Review).Molecular medicine reports · 2026Review
- From Byproduct to Regulator: The Expanding Role of Lactate and Lactylation in Cardiovascular Physiology and Disease.Biology · 2026Review
- The lactate shuttle in ageing: a metabolic bridge between muscle fatigue and brain resilience.Frontiers in physiology · 2026Review
- Lactate metabolism and protein lactylation in colorectal cancer: from metabolic reprogramming to epigenetic regulation.Frontiers in oncology · 2026Review
- Development and internal validation of a multidimensional nomogram integrating PIV, LDH, and FeNO for predicting poor asthma control in school-aged children.Frontiers in pediatrics · 2026Article
- Molecular Mechanisms Driving Metastatic Progression Within the Aged Tumor Microenvironment.International journal of molecular sciences · 2025Review
- Erythrocytes as a Source of Exerkines.International journal of molecular sciences · 2025Review
- Lactylation in post-stroke fatigue: linking metabolic dysregulation to neuroinflammation.Frontiers in neuroscience · 2025Review
- Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases.Frontiers in immunology · 2025Review
- Evaluating lymphocyte change rate and lactate as predictors of prognosis in critical COVID-19 patients in the intensive care unit.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactate, traditionally seen as a byproduct of anaerobic metabolism, has gained attention for its dual role in human health. While it is associated with muscle fatigue, lactate also plays a crucial role in various physiological and pathological processes. This review explores lactate's dual nature as both beneficial and detrimental. Under normal physiological conditions, lactate is an essential energy substrate, involved in the Cori cycle, where it is converted back to glucose in the liver. However, excessive lactate accumulation is linked to health issues, including cancer, metabolic disorders, and neurological diseases. The Warburg effect in cancer, characterized by increased lactate production even in oxygen-rich environments, promotes tumor progression and therapy resistance. In diseases like malaria and ischemic stroke, high lactate levels contribute to tissue damage and metabolic disturbances. Recent research also highlights lactate's beneficial roles, including regulation of immune responses, enhanced exercise performance, and neuronal signaling. Furthermore, gut microbiota significantly impacts lactate metabolism, where beneficial bacteria use lactate to maintain gut health, while some pathogenic bacteria exacerbate disease through excess lactate production. Emerging therapeutic potential of lactate, including lactate dehydrogenase inhibitors, offers promising treatment avenues. This review provides a comprehensive overview of lactate's complex role in health and disease, emphasizing the need for targeted strategies to harness its benefits while mitigating its harmful effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.