Evidence map›Paper›PMID 40821874›Full record

ArticleACS polymers Au2025

Low-Cost, Disposable Biosensor for Detection of the Brain-Derived Neurotrophic Factor Biomarker in Noninvasively Collected Saliva toward Diagnosis of Mental Disorders.

Nathalia O Gomes, Marcelo L Calegaro, Luiz Henrique C Mattoso, Sergio A S Machado, Osvaldo N Oliveira, Paulo A Raymundo-Pereira

Abstract read
In one paragraph

Article in ACS polymers Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Orbitofrontal BDNF puts the brakes on alcohol intake and relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathalia O GomesSao Carlos Institute of Chemistry, IQSC-USP, University of Sao Paulo, 13566-590 Sao Carlos, São Paulo, Brazil.
Marcelo L CalegaroSao Carlos Institute of Chemistry, IQSC-USP, University of Sao Paulo, 13566-590 Sao Carlos, São Paulo, Brazil.
Luiz Henrique C MattosoNanotechnology National Laboratory for Agribusiness (LNNA), Embrapa Instrumentation, 13561-206 São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7586-1014
Sergio A S MachadoSao Carlos Institute of Chemistry, IQSC-USP, University of Sao Paulo, 13566-590 Sao Carlos, São Paulo, Brazil.
Osvaldo N OliveiraSao Carlos Institute of Physics, IFSC-USP, University of Sao Paulo, 13566-590 Sao Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5399-5860
Paulo A Raymundo-PereiraSao Carlos Institute of Physics, IFSC-USP, University of Sao Paulo, 13566-590 Sao Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-0379-1592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of early detection of neurodegenerative disorder biomarkers has grown since these biomarkers are essential for timely diagnosis, treatment, healthcare, and wellness applications. We present a cost-effective and disposable electrochemical immunosensing strip for rapid, decentralized detection of brain-derived neurotrophic factor (BDNF)one of the major neurotrophins (NTs) associated with neurological and psychiatric disordersin human saliva. The salivary BDNF immunosensor strip is made on a screen-printed carbon electrode functionalized with carbon spherical shells (CSSs), polyethylenimine (PEI), and glutaraldehyde to enhance sensitivity. Through systematic optimization, the sensor achieved excellent analytical performance, with a wide dynamic detection range from 1.0 × 10

Indexed as

BDNFdiagnosisdisposable biosensorshuman salivamajor depressive disorder (MDD)therapeutic drug monitoring

Identifiers

PMID40821874
PMCPMC12355618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.