Evidence map›Paper›PMID 40821852›Full record

ArticleMolecular therapy. Methods & clinical development2025

A rescue fanconi anemia humanized mouse model with endogenous FA mutation and high human hematopoietic stem cell chimerism.

Seunga Choo, Alvin H Tong, Emily Fields, Heather M Mack, Olivier Humbert, Stefan Radtke, Hans-Peter Kiem

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seunga ChooDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Alvin H TongDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Emily FieldsDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Heather M MackDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Olivier HumbertDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Stefan RadtkeDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Hans-Peter KiemDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
Nongenotoxic conditioning for gene therapy and allogeneic transplantation in Fanconi anemiaR01HL147324 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Bruce R Blazar, HANS-PETER KIEM · 2020 to 2026
$4.1M
NHLBI NIH HHS R01 HL147324NHLBI NIH HHS T32 HL007093NIDDK NIH HHS U54 DK106829
6 · The paper itself

Abstract

Autologous transplantation of

Indexed as

Fanconi anemiagene editinggene therapyhumanized mouse model

Identifiers

PMID40821852
PMCPMC12355547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.