Evidence map›Paper›PMID 40821849›Full record

ArticleFrontiers in immunology2025

Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model.

Jenny Lorena Molina Estupiñan, Poorya Foroutan Pajoohian, Gabriel Kristian Pedersen, Dennis Christensen, Serena Marchi, Emanuele Montomoli, Stefanía P Bjarnarson, Ingileif Jonsdottir, Audur Anna Aradottir Pind

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenny Lorena Molina EstupiñanFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.
Poorya Foroutan PajoohianFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.
Gabriel Kristian PedersenCenter for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
Dennis ChristensenCenter for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
Serena MarchiDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Emanuele MontomoliDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Stefanía P BjarnarsonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.
Ingileif JonsdottirFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.
Audur Anna Aradottir PindFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood vaccination provides protection against infectious diseases, but multiple vaccinations are required to achieve this. In situations like influenza epidemics or COVID-19 pandemic, vaccine demands may exceed production capacity, highlighting the need for dose-sparing strategies. Adjuvants can boost and modulate immune responses to vaccines and could reduce the antigen doses needed to confer protection. Herein we evaluated the dose-sparing effects of the novel adjuvants dmLT, mmCT, CAF01, and CAF08b and alum (aluminum hydroxide) on primary neonatal antibody (Ab) response to a conjugate vaccine against

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineAluminum HydroxideInfluenza VaccinesPneumococcal VaccinesAnimalsAnimals, NewbornAntibodies, BacterialAntibodies, ViralFemaleHumansMiceMice, Inbred BALB CStreptococcus pneumoniaeVaccinationVaccines, ConjugateAdjuvants, ImmunologicAdjuvants, VaccineAluminum HydroxideAntibodies, BacterialAntibodies, ViralInfluenza VaccinesPneumococcal VaccinesVaccines, Conjugateadjuvantsantibodiesantibody-secreting cellsdose-sparingimmunizationneonates

Identifiers

PMID40821849
PMCPMC12350264

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.