ArticleFrontiers in immunology2025
The critical role of diet, exercise, and sleep in shaping the gut microbiota of children with idiopathic short stature: a Retrospective study.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Objectives: To investigate the gut microbiota in children with varying degrees of idiopathic short stature (ISS) and to examine the relationship between their intestinal microbiota and lifestyle factors, including diet, exercise, medication, sleep, and psychological state. Methods: A retrospective study involving 58 ISS children was conducted from May to October 2022. Lifestyle data were collected using questionnaires. Fecal samples were analyzed using 16S rRNA gene sequencing to assess microbiota diversity and composition. LEfSe analysis identified differential bacterial communities between ISS-2SD and ISS-3SD groups (LDA score ≥ 2.5). Spearman correlation analysis explored the relationship between microbiota diversity, dominant taxa, and lifestyle factors, visualized in a heatmap. Results: No significant differences in alpha diversity of intestinal microbiota were observed among children with varying degrees of short stature at the ISS, but differences were noted in the dominant microbiota. The ISS-2SD group had Conclusion: Children with varying degrees of short stature exhibited differences in their dominant intestinal microbiota. Diet, exercise, and sleep appear to be significant factors influencing these microbial changes in ISS children.
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