ArticleFrontiers in immunology2025
Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Review
- An epithelial mesenchymal transition associated gene signature stratifies risk of ulcerative colitis associated colorectal cancer.Discover oncology · 2026Article
- Higher Colonic Tissue Drug Concentrations of Subcutaneous Compared to Intravenous Administration of Infliximab Therapy in Patients With Inflammatory Bowel Disease.United European gastroenterology journal · 2026Observational
- A reproducible pretreatment mucosal-inflammatory-remodeling state is associated with induction-phase anti-tumor necrosis factor non-response in ulcerative colitis.Frontiers in genetics · 2026Article
- The role ofFrontiers in immunology · 2025Review
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Authors and funding
7 authors.
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Abstract
Background: Inflammatory bowel disease (IBD) presents unpredictable therapeutic responses and complex immune dysregulation. Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance. Methods: We performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. Validation employed ten algorithms and nomogram construction. Immune infiltration (CIBERSORT/ssGSEA), single-cell RNA sequencing, and DSS-colitis models characterized immune dynamics, cellular specificity, and therapeutic response modulation. Results: We identified 536 differentially expressed genes significantly enriched in IL-17 signaling, TNF signaling, and cytokine-cytokine receptor interactions. WGCNA revealed six co-expression modules with disease-specific correlations: turquoise module strongly correlated with Crohn's disease (r=0.6, P=4×10 Conclusion: This mechanistically grounded four-gene signature enables precise IBD patient stratification across distinct immunological subtypes and predicts biologic responses, providing validated molecular tools for precision immunotherapy and personalized treatment optimization.
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