ArticleFrontiers in immunology2025
HER2-positive breast cancer with invasive micropapillary carcinoma component shows immunosuppressive microenvironment and resistance to neoadjuvant therapy.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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15 authors.
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Abstract
Background: Invasive micropapillary carcinoma (IMPC) is a rare histopathological subtype of breast cancer (BC) that shows a high incidence of human epidermal growth factor receptor 2 (HER2)-positive expression. However, the therapeutic efficacy of current standard anti-HER2 therapies for this distinct BC subtype remains unclear. Methods: We retrospectively analyzed patients with HER2-positive BC who underwent neoadjuvant therapy with trastuzumab (H) or trastuzumab plus pertuzumab (HP) between 2015 and 2023 at Sun Yat-sen University Cancer Center. On the basis of the presence of an IMPC component in pretreatment tumor samples, patients were stratified into IMPC and non-IMPC groups. Baseline clinical and pathological characteristics, pathological complete response (pCR) rates, and survival outcomes were compared between two groups. Additionally, gene expression profiles and immune cells infiltration were assessed using GSE66418 dataset obtained from the Gene Expression Omnibus and ImmuCellAI databases. To validate bioinformatics findings, matched pretreatment tumor samples from both groups were analyzed. Results: Among the 244 patients included in the study, 38 had an IMPC component (IMPC group), whereas 206 did not (non-IMPC group). The IMPC group exhibited significantly lower pCR rates compared to the non-IMPC group: 21.6% vs. 47.1% ( Conclusion: HER2-positive BC with IMPC demonstrates intrinsic resistance to anti-HER2 neoadjuvant therapy and harbors an immunosuppressive TME. These findings highlight the need for alternative treatment strategies and warrant prospective validation.
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