Evidence map›Paper›PMID 40821763›Full record

ArticleMathematics (Basel, Switzerland)2024

Homological landscape of human brain functional sub-circuits.

Duy Duong-Tran, Ralph Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick Xu, Jingxuan Bao, Enrico Amico, Alan D Kaplan, Giovanni Petri and 3 more

Abstract read
In one paragraph

Article in Mathematics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Characterizing Amyloid Pathogenic Spread in Alzheimer's Disease Through A Network Diffusion Model.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2025
    Article
  6. Causality-based Subject and Task Fingerprints using fMRI Time-series Data.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2024
    Article
  7. Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024
    Article
  8. Article
  9. Volume-optimal persistence homological scaffolds of hemodynamic networks covary with MEG theta-alpha aperiodic dynamics.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2024
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Duy Duong-TranDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Ralph KaufmannDepartment of Mathematics, Purdue University, West Lafayette, IN, USA.
Jiong ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Xuan WangDepartment of Electrical and Computer Engineering, George Mason University, Fairfax, VA, USA.
Sumita GaraiDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Frederick XuDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Jingxuan BaoDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.
Enrico AmicoNeuro-X Institute, EPFL, Geneva, Switzerland.
Alan D KaplanComputational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Giovanni PetriCENTAI Institute, 10138 Torino, Italy.
Joaquin GoniPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA.
Yize ZhaoSchool of Public Health, Yale University, New Heaven, CT, USA.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, PA, USA.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
Novel integrative imaging genetics analysis for Alzheimer's disease riskand progressionRF1AG068191 · NIA · YALE UNIVERSITY · PI ZHAO, YIZE · 2021 to 2021
$1.9M
Cross-disciplinary training in translational neuroimaging of ADRDT32AG076411 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHN A DETRE, MURRAY GROSSMAN · 2022 to 2026
$1.5M
NIA NIH HHS R01 AG071470NIA NIH HHS RF1 AG068191NIA NIH HHS T32 AG076411NIA NIH HHS U01 AG068057NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Human whole-brain functional connectivity networks have been shown to exhibit both local/quasilocal (e.g., set of functional sub-circuits induced by node or edge attributes) and non-local (e.g., higher-order functional coordination patterns) properties. Nonetheless, the non-local properties of topological strata induced by local/quasilocal functional sub-circuits have yet to be addressed. To that end, we proposed a homological formalism that enables the quantification of higher-order characteristics of human brain functional sub-circuits. Our results indicated that each homological order uniquely unravels diverse, complementary properties of human brain functional sub-circuits. Noticeably, the

Indexed as

Functional NetworksFunctional sub-circuitHomological kernelTopological data analysis

Identifiers

PMID40821763
PMCPMC12352577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.