Evidence map›Paper›PMID 40821760›Full record

ArticleJournal of translational autoimmunity2025

T-cell immunity in the experimental autoimmune vasculitis rat model.

Ye Zeng, Erika Boschmann, Julia Kotte, Ming Sun, Lennart Hess, Sebastian Dolff, Tanja Hinkeldein, Janna Hagedorn, Robert Langer, Pieter van Paassen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ye ZengDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Erika BoschmannDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Julia KotteDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ming SunDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Lennart HessDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sebastian DolffDepartment of Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Tanja HinkeldeinDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Janna HagedornDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Robert LangerDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Pieter van PaassenDepartment of Internal Medicine, Section of Immunology, Maastricht University Medical Center, Maastricht, the Netherlands.
Jan DamoiseauxCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands.
Jan Willem Cohen TervaertDepartment of Medicine, Division of Rheumatology, University of Alberta, Edmonton, Canada.
Oliver WitzkeDepartment of Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Andreas KribbenDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It was the aim to analyze the lesional T-cell dynamics in the experimental autoimmune vasculitis model. Female Wistar Kyoto-rats were immunized with human MPO emulsified in complete Freund's adjuvant. Control animals received complete Freund's adjuvant without MPO. Selected groups received anti-IL17A treatment. Lesional T-cells from kidneys were assessed by flow cytometry (FACS), realtime polymerase chain reaction (PCR) and EliSpot. All animals immunized with MPO developed signs of vasculitis. At week six, lung damage expressed as petechial bleeding score and renal damage quantified by albuminuria were highest. As analyzed by FACS, the fraction of renal Th17 cells peaked at week six in MPO rats equaling the proportion of Th1 cells. MPO-specific renal Th1 and Th17 cells were detectable by EliSpot at weeks four and six post-immunization in MPO-immunized rats being absent in control rats. Neutralization of IL-17A did not affect the development of humoral and cellular anti-MPO immunity. Likewise, pulmonary and renal vasculitis were not ameliorated. In summary, the dynamics of the lesional T-cell response in the EAV model shows a major participation of MPO-specific Th17 and Th1 cells in renal vasculitis. Simple cytokine neutralization was not efficacious in this disease model so that combined neutralization approaches should be studied further.

Indexed as

ANCA vasculitisMPOPR3Th17 cellsTh1 cells

Identifiers

PMID40821760
PMCPMC12356024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.