ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Associations Between Fatigue and Cardiovascular-Kidney-Metabolic Syndrome and the Mediating Role of Inflammation.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cardiovascular-kidney-metabolic syndrome: a comprehensive review of pathophysiology, epidemiology, diagnosis, and management.Cardiovascular diabetology · 2026Review
- From Activity Screening to Quality Control: UHPLC-MS/MS Analysis of Anti-Inflammatory Cyclodipeptides inMolecules (Basel, Switzerland) · 2026Article
- Symptom experience subtypes and their association with social isolation in older adults with diabetes and coronary heart disease: a latent profile analysis study.Frontiers in medicine · 2026Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Fatigue is common in many chronic diseases. The aim of this cross-sectional study was to investigate the association between fatigue and cardiovascular-kidney-metabolic syndrome (CKM) in Chinese asymptomatic individuals undergoing routine health screenings and to explore the mediating role of inflammation. Patients and Methods: The data of 4349 individuals were included in this cross-sectional study. Fatigue was measured with the Fatigue Severity Scale (FSS). The association between fatigue and the severity of CKM syndrome was evaluated via logistic regression analysis. The mediating role of inflammation in fatigue and advanced CKM syndrome was explored using mediation analysis. Results: A total of 4349 participants were included in this study, and 2120 (48.7%) experienced fatigue. Fatigue was associated with a greater risk of developing advanced CKM syndrome (OR 2.597, 95% CI 1.323-5.097, Conclusion: Fatigue is significantly associated with the increased risk of advanced CKM syndrome, especially in young and middle-aged adults. The cause of this association may be that white blood cell count and neutrophil count play a partial role in this relationship.
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