ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Article
- Prevalence of hyperuricemia and its associations with hyperinsulinemia and hepatic injury among adolescents with obesity in Guangxi, China.Frontiers in nutrition · 2026Article
- Subphenotyping Obesity in Pursuit of Personalized Medicine: The Devil is in the Details.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Higher serum uric acid levels are associated with improved outcomes in acute ischemic stroke patients following intravenous thrombolysis with alteplase-a retrospective cohort study.Frontiers in neurologyArticle
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7 authors.
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Abstract
Background: Overweight and obesity in children and adolescents have emerged as significant public health issues in China. This study aims to analyze the characteristics of serum uric acid (SUA) metabolism in overweight and obese children and adolescents in South China, exploring its associations with metabolic parameters. Methods: A single-center retrospective study was conducted, involving children and adolescents aged 3 to 18 years diagnosed with overweight and obesity. Spearman correlation coefficients were calculated to evaluate relationships between SUA and other metabolic parameters. Multivariate linear regression analyses were conducted to adjust for confounders. Comparisons were made between participants with hyperuricemia and those with normal SUA levels, and logistic regression analyses were conducted to adjust for confounders. Hierarchical clustering was performed to explore the relationships among the parameters. A dendrogram was generated to visualize the cluster structure. Results: Among 172 participants (96 males, 76 females), the mean age was 10.88±2.70 years. The prevalence of hyperuricemia was 36.30%, with 38.46% in males and 33.82% in females. Every 1 kg/m² increase in body mass index was associated with a 7.156 µmol/L increase in SUA and an 8.9% increase in hyperuricemia risk. Significant correlations were observed between SUA levels and insulin resistance (HOMA-IR), fasting insulin, and high-density lipoprotein cholesterol. Hierarchical clustering analysis revealed two distinct clusters. One cluster includes SUA along with insulin resistance and lipid metabolism parameters, while the other comprises obesity metrics, urinary microalbumin, and blood glucose. Conclusion: The findings show a high prevalence of hyperuricemia in overweight and obese children and adolescents, linked to insulin resistance and dyslipidemia. These results highlight the need for early screening and targeted interventions to improve metabolic health outcomes in this vulnerable population.
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