ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2025
Effectiveness of Personalized Nutrition on Management Diabetes Mellitus Type 2 and Prediabetes in Adults: A Systematic Review.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gene-Diet Interactions in Type 2 Diabetes: A Systematic Review of Observational Studies and Clinical Trials.Nutrients · 2026Pooled it
- Pooled it
- Beyond One-Size-Fits-All: Individually Tailored Dietary Interventions in Modern Obesity Care.Nutrients · 2026Review
- Economic Impact of a Precision Nutrition Digital Therapeutic on Employer Health Costs: A Multi-Employer and Multi-Year Claims Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Nutrigenomics meets multi-omics: integrating genetic, metabolic, and microbiome data for personalized nutrition strategies.Genes & nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetes mellitus type 2 and prediabetes are diet-related diseases with varied individual responses to routine dietary interventions. Personalized nutrition, a novel approach tailored to individual variability in response to nutrients, may offer improved outcomes. Purpose: This systematic review analyzed the effectiveness of personalized nutrition compared to control diet for managing diabetes mellitus type 2 and prediabetes. Methods: A comprehensive search was conducted in Medline, PubMed, and Cochrane CENTRAL for randomized controlled trials (RCTs) published in English up to March 31, 2024. Studies involving humans were screened independently by two reviewers, who also extracted data and assessed study quality using the Risk of Bias 2 tool. The SWiM (Synthesis Without Meta-Analysis) approach was used to summarize effect estimates and combine p-values. Results: Eight studies, including five RCTs, met the inclusion criteria. Two studies had high risk of bias and another six had some concern bias. Personalized nutrition significantly reduced HbA1c (median mean difference: -0.925%, p < 0.01, 4 studies), though the effect was minimal in studies with some concern of bias (-0.035%). Fasting glucose showed no significant change (p = 0.12, 2 studies) in prediabetics, while PPGR improved significantly (-14.85 mg/dLxh, p < 0.01, 2 studies). Energy intake did not significantly differ (p = 0.06). Personalized nutrition reduced body weight (-0.58%) compared to control only when including high-risk studies; this effect was not significant in lower-risk studies (p = 0.06). Personalized nutrition also significantly reduced carbohydrate intake (-10.8% of energy, p = 0.02) compared to control diet. It also improved gut microbiome diversity and richness from baseline in prediabetics. Conclusion: Personalized nutrition shows promise in improving HbA1c, PPGR, and reducing carbohydrate intake, with potential effects on body weight, in adults with diabetes mellitus type 2 or prediabetes. Effects on fasting glucose and energy intake remain unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.