Evidence map›Paper›PMID 40821737›Full record

ArticleTherapeutic advances in gastroenterology2025

Artificial intelligence-based multimodal model for the identification of ulcerative colitis with concomitant cytomegalovirus colitis.

Haozheng Liang, Yuxuan Tian, Gechong Ruan, Xiaoyin Bai, Wei Han, Xiangling Fu, Yuhang Wang, Jialin Shi, Yinghao Sun, Ji Wu and 2 more

Abstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. ChatGPT-Assisted Image Interpretation for Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haozheng LiangDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0009-0002-7894-2965
Yuxuan TianDepartment of Electronic Engineering and the Institute for Precision Medicine, Tsinghua University, Beijing, China.
Gechong RuanDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiaoyin BaiDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0002-9092-7592
Wei HanInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Xiangling FuSchool of Computer Science (National Pilot Software Engineering School), Beijing University of Posts and Telecommunications, Beijing, China.
Yuhang WangSchool of Computer Science (National Pilot Software Engineering School), Beijing University of Posts and Telecommunications, Beijing, China.
Jialin ShiSchool of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, China.
Yinghao SunDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Ji WuDepartment of Electronic Engineering and the Institute for Precision Medicine, Tsinghua University, Haidian District, Beijing, 100084, China.
Chenyi GuoDepartment of Electronic Engineering and the Institute for Precision Medicine, Tsinghua University, Haidian District, Beijing, 100084, China.
Hong YangDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China.ORCID https://orcid.org/0000-0002-2986-7324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ulcerative colitis (UC), a chronic immune-mediated colon inflammation, impacts patients' quality of life. Immunosuppressive-treated UC patients are prone to opportunistic infections like cytomegalovirus (CMV) infection, which exacerbates UC, causes steroid resistance, and elevates surgery and mortality risks. Identifying CMV colitis from UC exacerbation is difficult due to overlapping symptoms and low biopsy detection rates. Objectives: To develop an artificial intelligence (AI)-based multimodal model for early identification of UC with concomitant CMV colitis. Design: This was a retrospective diagnostic study. Methods: A total of 174 moderate to severe UC patients (87 with CMV colitis) from 2015 to 2023 in Peking Union Medical College Hospital were enrolled retrospectively. A total of 3345 colonoscopy images were collected. The dataset was split into training (70%) and testing (30%) sets. A multimodal dynamic affine transformation (DAFT) model integrating clinical biomarkers and endoscopic images was constructed, along with ResNet and SeNet models. Model performance was evaluated using accuracy, sensitivity, specificity, positive and negative predictive values from the confusion matrix. Results: UC patients with CMV colitis had distinct clinical characteristics. The multimodal DAFT model outperformed ResNet and SeNet in distinguishing UC with CMV colitis, with higher accuracy (0.91), sensitivity (0.87), and specificity (0.93). Conclusion: AI application offers a promising way to enhance early identification of UC with CMV colitis. The multimodal model combining clinical and endoscopic data can assist clinicians in accurate and timely diagnosis.

Indexed as

artificial intelligencecytomegalovirus colitisdeep learningmultimodal modelulcerative colitis

Identifiers

PMID40821737
PMCPMC12357019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.