Evidence map›Paper›PMID 40821700›Full record

ArticleFrontiers in molecular biosciences2025

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma.

Liang Chu, Han Wang, Tao Ling, Shuhan Feng, Yucheng Ding, Yan Zhang, Ying Pan, Cenzhu Wang, Xiaohong Wang, Lei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liang Chu *Department of Surgery, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Han Wang *Clinical Laboratory, Hainan Medical University, Haikou, Hainan, China.
Tao Ling *Department of Gastroenterology, Jinhua Central Hospital Affiliated to Zhejiang University School of Medicine, Jinhua, China.
Shuhan FengDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Yucheng DingDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Yan ZhangDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.
Ying PanInpatient Management Center, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
Cenzhu WangDepartment of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Xiaohong WangDepartment of Gastroenterology, XuZhou Central Hospital Affiliated to Medical School of Southeast University, XuZhou, China.
Lei LiuDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC). Methods: A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models. A nomogram model was developed to predict outcomes. Results: High-LNR, TD-positive, and PNI-positive were associated with poorer CSS and OS in both the training and validation cohorts. Multivariate Cox analysis identified T stage, M stage, TD, CEA, chemotherapy, and LNR as independent prognostic factors. A prognostic nomogram model incorporating these variables demonstrated excellent calibration and satisfactory predictive accuracy. Survival curves generated from individualized nomogram scores effectively discriminated prognostic outcomes ( Conclusion: LNR, TD, and PNI served as prognostic factors for advanced colorectal SRCC. The combined analysis demonstrated a higher prognostic predictive value.

Indexed as

colorectal signet ring cell carcinomalymph node ratioperineural invasionprognosistumor deposit

Identifiers

PMID40821700
PMCPMC12355033

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.