ArticleJournal of medical biochemistry2025
Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Matriptase-2 (MT2) is implicated in iron metabolism, obesity, insulin resistance, and glucose homeostasis. Neurokinin B (NKB) plays a crucial role in gonadotropin secretion, which is essential for reproduction. The impact of menopause and obesity on MT2 and NKB concentrations remains an enigma. Therefore, the present study sought to investigate how obesity and menopause affect serum concentrations of MT2 and NKB. Methods: In this cross-sectional study, 120 female volunteers were divided into four groups: menopausal overweight, menopausal obese, menopausal normal weight (control), and reproductive normal weight (control). The participants' serum levels of MT2, NKB, iron, ferritin, and relevant biochemical parameters were analysed using the ELISA method. Results: The mean serum concentrations of NKB, MT2, and ferritin were higher in the menopausal overweight and obese groups (p<0.05). The mean concentrations of NKB, MT2, and estradiol were determined to be higher, and the levels of iron, hemoglobin, glucose, FSH, LH, LDL, and total cholesterol were found to be lower in the reproductive control group when compared with the menopausal control group (p<0.05). A positive correlation was identified between BMI and NKB, MT2, and ferritin concentrations in menopausal overweight and obese groups (p<0.05). Conclusions: Obesity elevated NKB and MT2 concentrations in menopausal women. The increase in MT2 levels in menopausal overweight or obese women may be one of the factors responsible for the increase in ferritin and body fat ratio. As BMI raised, NKB, MT2, and ferritin concentrations raised in the menopausal overweight or obese groups; therefore, depression of MT2 in obese patients could be beneficial for therapeutic purposes. Additionally, gonadal hormonal changes altered serum concentrations of NKB, and the increase in NKB and gonadotropin levels in menopause may enhance vasomotor symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.