ReviewJAAD international2025
The role of the skin microbiome in inherited ichthyoses: A systematic review.
Review in JAAD international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inherited ichthyoses (iI) are a heterogeneous group of keratinization disorders, whose microbiome composition and the role of dysbiosis remain largely unexplored. Objectives: Characterization of the skin microbiome profile in iI and exploration of the significance of dysbiosis based on the literature. Methods: A systematic search was performed across MEDLINE, Embase, Cochrane Library, Web of Science, and Scopus on 23 September 2024. Studies with culture-based and molecular diagnostic methods were included. Results: 1923 records were retrieved, and 13 met our inclusion criteria. The studies identified focused on non-syndromic and syndromic ichthyosis genotypes. Significant dysbiosis was observed in iI subtypes, with altered alpha and beta diversity. Subtype-specific alterations included elevated levels of pathogenic bacteria, such as Limitations: The heterogeneity of studies is a limitation. Conclusions: These findings emphasize the distinct microbiome profiles of different iI subtypes, marked by an imbalance, enrichment of pathogenic microorganisms, and a reduction in protective microbes. This dysbiosis is linked to disease severity and inflammation.
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