ArticleProceedings (Baylor University. Medical Center)2025
Efficacy and safety of iron supplements for restless leg syndrome, a systematic review, meta-analysis, meta-regression, and trial sequential analysis of randomized controlled trials.
Article in Proceedings (Baylor University. Medical Center), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Restless leg syndrome (RLS) is a common neurological condition that can affect the quality of life. Iron is one of the available options for the treatment of RLS. Methods: This systematic review and meta-analysis assessed the efficacy and safety of different iron regimens in treating RLS. We searched EMBASE, SCOPUS, Web of Science, PubMed, and Cochrane databases for studies that assessed the effects of different iron supplements compared to placebo on the International RLS score (IRLS), RLS-Quality of Life (QOL) score, sleep visual analog score (VAS), and adverse events (AEs). Results: Twelve randomized controlled trials with 511 patients were included. Iron improved the IRLS score (mean difference [MD] = -5.28; 95% confidence interval [CI] - 7.66, -2.90; Conclusion: Iron, especially ferric carboxymaltose, is a valuable option for RLS, which showed improvement in several indices.
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