Evidence map›Paper›PMID 40821438›Full record

ArticleData in brief2025

Seahorse-assessed metabolic data, CAM assay data and aspect ratio data of tenocyte in vitro cultures treated with insulin-like growth factor-1 (IGF-1), with platelet-derived growth factor-BB (PDGF-BB) or with IGF-1 and PDGF-BB simultaneously.

Julia Rieber, Petra Wolint, Gabriella Meier-Bürgisser, Esteban Ongini, Pietro Giovanoli, Maurizio Calcagni, Jess G Snedeker, Johanna Buschmann

Abstract read
In one paragraph

Article in Data in brief, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia RieberDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Petra WolintDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Gabriella Meier-BürgisserDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Esteban OnginiBalgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Pietro GiovanoliDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Maurizio CalcagniDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.
Jess G SnedekerBalgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.
Johanna BuschmannDivision of Plastic Surgery and Hand Surgery, University Hospital of Zurich, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As tendon rupture repair still implies problematic outcomes for the patients, such as re-rupture or adhesion formation to the surrounding tissue, restricting the capability for full loading or the range of motion, novel approaches are welcome and many research groups are working on the optimization of tendon repair. For example, growth factor delivery to the ruptured tendon may support the natural healing by accentuating growth factor dynamics that otherwise occur naturally. We have therefore tested insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor-BB (PDGF-BB) or both mixed together under in vitro conditions, supplementing the growth factors to cell culture medium of rabbit Achilles tenocytes and rabbit adipose-derived stem cells. We have assessed the effects on the cell morphology and provide aspect ratio data, as well as metabolic data determined by Seahorse experiments, and finally CAM assay data referring to several angiogenic readouts, respectively.

Indexed as

AngiogenesisMetabolismTendon repairTenocytes

Identifiers

PMID40821438
PMCPMC12356399

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.