Evidence map›Paper›PMID 40821415›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2025

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics.

Christopher McPherson, Rachel S Meyers, Jennifer Thackray, Danielle L Stutzman, Kimberly P Mills, Sana J Said, Karisma Patel, Robert C Hellinga, Amy L Potts, Lisa Lubsch and 2 more

Abstract read
In one paragraph

Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Characterizing the Safety and Efficacy of Propofol in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  2. Implementation of a Pharmacogenomic Service in a Pediatric Community Hospital.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  3. Opioid Use in Children.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  4. Safety and Efficacy of Oral Azithromycin for Gastrointestinal Dysmotility in Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  5. Review
  6. Review
  7. Preventing Medication Errors in Paediatrics: A Narrative Review.Clinical medicine insights. Pediatrics · 2026
    Review
  8. Article
  9. Article
  10. A Structured Approach to Identifying and Addressing Drug Therapy Problems in Neonatal and Pediatric Critically Ill Patients: IN-DEPTH.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher McPhersonSt. Louis Children's Hospital (CM, KPM), St. Louis, MO.
Rachel S MeyersErnest Mario School of Pharmacy, Rutgers University (RSM), Piscataway, NJ.
Jennifer ThackrayMemorial Sloan Kettering Cancer Center (JT), New York, NY.
Danielle L StutzmanPediatric Mental Health Institute at Children's Hospital Colorado (DLS), Aurora, CO.
Kimberly P MillsSt. Louis Children's Hospital (CM, KPM), St. Louis, MO.
Sana J SaidComer Children's Hospital (SJS), Chicago, IL.
Karisma PatelChildren's Health (KP), Dallas, TX.
Robert C HellingaPhoenix Children's Hospital (RCH); Phoenix, AZ.
Amy L PottsMonroe Carrell Jr. Children's Hospital at Vanderbilt (ALP), Nashville, TN.
Lisa LubschSouthern Illinois University Edwardsville School of Pharmacy (LB), Edwardsville, IL.
Kelly L MatsonUniversity of Rhode Island College of Pharmacy (KLM), Kingston, RI.
David S HoffIndependent Consultant (DSH), Lakeville, MN.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveThe objective was to update the KIDs List, a list of drugs and excipients that are potentially inappropriate for use in pediatric patients, accounting for emerging pharmacologic agents and published evidence.

methodsA panel of 12 pediatric pharmacists from the Pediatric Pharmacy Association (PPA) evaluated primary, secondary, and tertiary literature; FDA Pediatric Safety Communications; the UpToDate Lexidrug database; and product information for drugs that may be considered potentially inappropriate for use in pediatric patients. A PubMed search identified new publications from October 1, 2017, to November 1, 2023. All agents included in the previous publication and those anecdotally identified as candidates for the list by the authors or PPA members were evaluated. Evidence was reviewed by all authors. The draft list underwent a 30-day public comment period prior to being finalized.

resultsA PubMed search yielded 917 unique titles of which 17 were deemed relevant for full review. Sixty-seven drugs and/or drug classes and 10 excipients from the original publication were also reviewed. Author and PPA member recommendations highlighted an additional 25 drugs or drug classes. The UpToDate Lexidrug database extraction yielded 1470 drugs, which were filtered to 145 agents for author review. After critical analysis and reorganization, the second edition of the KIDs List contains 39 drugs and/or drug classes and 10 excipients.

conclusionsThis article updates the initial list of drugs and excipients that are potentially inappropriate for prescribing in all or a select subgroup of pediatric patients. The second edition should stimulate novel research to inform future updates.

Indexed as

adverse drug eventadverse drug reactionexcipientsmedicationspediatricspotentially inappropriate medication list

Identifiers

PMID40821415
PMCPMC12351480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.