ArticleBiological psychiatry global open science2025
Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.
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Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Who cites it
8 citing papers in PubMed.
- Glial-neuronal crosstalk via GABA signaling: mechanistic insights into neuropsychiatric and neurological pathophysiology.Molecular psychiatry · 2026Review
- ATP and major affective disorders: the involvement of P2X receptors in pathophysiology.Purinergic signalling · 2026Review
- Genetic Polymorphisms Associated with Lithium Response in Bipolar Disorder: An Integrative Review and In Silico Protein-Protein Interaction Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Lithium Therapeutic Functions: An Update on Pharmacokinetics, Pathophysiological Mechanisms of Action, Toxicity, and Side Effects.Molecular neurobiology · 2026Review
- Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.International journal of molecular sciences · 2026Review
- Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Polygenicity at the pathway level for anorexia nervosa.medRxiv : the preprint server for health sciences · 2025Article
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Authors and funding
162 authors.
Nigussie T SharewDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Scott R ClarkDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, San Diego, California.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasUnitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina, University of Barcelona, CIBERSAM, Barcelona, Spain.
Roland HaslerDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Hélène Richard-LepourielDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Nader PerroudDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, San Diego, California.
Frank BellivierInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Antonio BenabarreBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Armin BirnerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Cynthia Marie-ClaireInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Pablo CervantesNeuromodulation Unit, McGill University Health Centre, Montreal, Quebec, Canada.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonHuman Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Bruno ÉtainInstitut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, L'Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Stephane JamainInserm U955, Fondation FondaMental, Translational Psychiatry Laboratory, Créteil, France.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Louise FrisenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
Sébastien GardPôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Maria Grigoroiu-SerbanescuDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Andreas J FallgatterBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Sophia StegmaierUniversity Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tübingen, Germany.
Thomas EthoferDepartment of General Psychiatry, University of Tübingen, Tübingen, Germany.
Silvia BiereDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Kristiyana PetrovaDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Ceylan SchusterDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Kristina AdorjanInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Maria HeilbronnerInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Mojtaba Oraki KohshourInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Daniela Reich-ErkelenzInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Sabrina K SchauppInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Eva C SchulteInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Fanny SennerInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Thomas VoglInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Ion-George AnghelescuDepartment of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany.
Volker AroltInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Detlef E DietrichAMEOS Clinical Center Hildesheim, Hildesheim, Germany.
Christian FiggeKarl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
Markus JägerDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Fabian U LangDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Georg JuckelDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Carsten KonradDepartment of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
Jens ReimerDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Max SchmaußDepartment of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Carsten SpitzerDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
Martin von HagenClinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Jörg ZimmermannPsychiatrieverbund Oldenburger Land GmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.
Till F M AndlauerDepartment of Neurology, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Andre FischerGerman Center for Neurodegenerative Diseases, University of Göttingen, Göttingen, Germany.
Felix BermpohlDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Philipp RitterDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Silke MaturaDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.
Anna GryaznovaInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Irina FalkenbergDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Cüneyt YildizDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Julia SchmidtInstitute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Marius KochInstitute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Kathrin GadeDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Sarah TrostDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Ida S HaussleiterDepartment of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
Martin LambertDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anja C RohenkohlDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Vivien KraftDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Paul GrofMood Disorders Center of Ottawa, Ottawa, Ontario, Canada.
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznań, Poland.
Stefan HermsInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Esther JiménezBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.
Layla KassemDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Saitama, Japan.
John KelsoeDepartment of Psychiatry, University of California San Diego, San Diego, California.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Ewa Ferensztajn-RochowiakDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.
Barbara KönigDepartment of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Gonzalo LajeDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Mikael LandénInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Marion LeboyerInserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.
Susan G LeckbandOffice of Mental Health, VA San Diego Healthcare System, San Diego, California.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institute, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, University of California San Diego, San Diego, California.
Susan McElroyDepartment of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, Ohio.
Francesc ColomMental Health Research Group, Hospital del Mar Medical Research Institute, Barcelona, Catalonia, Spain.
Vincent MillischerDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Marina MitjansDepartment of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Palmiero MonteleoneNeurosciences Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, California.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Tomas NovákNational Institute of Mental Health, Klecany, Czechia.
Claire O'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Norio OzakiDepartment of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Claudia PisanuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, San Diego, California.
Katzutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Christian SimhandlBipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czechia.
Mario MajDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Eduard VietaBipolar and Depressive Disorders Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Julia VeehInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Biju ViswanathDepartment of Psychiatry, National Institute of Mental Health and Neuroscience, Bangalore, India.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Adam WrightSchool of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, New South Wales, Australia.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Philip B MitchellSchool of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, New South Wales, Australia.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.
Bernhard T BauneDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
Klaus Oliver SchubertDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Azmeraw T AmareDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Funding
The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1MMapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0MCollaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9MCOLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6MHuman Genetics of Addiction: A Study of Common and Specific FactorsK02DA021237 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2007 to 2011
$567kDBT-Wellcome Trust India Alliance IA/CPHI/20/1/505266Intramural NIH HHS Z01 MH002810NCI NIH HHS P01 CA089392NIDA NIH HHS K02 DA021237NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068
Abstract
Background: Polygenic scores (PGSs) hold the potential to identify patients who respond favorably to specific psychiatric treatments. However, their biological interpretation remains unclear. In this study, we developed pathway-specific PGSs (PS Methods: Using sets of genes involved in pathways affected by lithium, we developed 9 PS Results: The PGSs for acetylcholine, GABA (gamma-aminobutyric acid), and mitochondria were associated with response to lithium in both categorical and continuous outcomes. However, the PGSs for calcium channel, circadian rhythm, and GSK (glycogen synthase kinase) were associated only with the continuous outcome. Each score explained 0.29% to 1.91% of the variance in the categorical and 0.30% to 1.54% of the variance in the continuous outcomes. A multivariate model combining PS Conclusions: PS
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Bipolar disorderLithiumPharmacogenomicsPolygenic scorePsychiatry
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