Unusual button sequestrum in multifocal epithelioid hemangioma of bone: A case report and literature review.

Larissa Girardi Sangoi, Joel Del Bel Pádua, Mateus de Andrade Hernandes, Marcello Henrique Nogueira-Barbosa, Leonor Garbin Savarese

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Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

5 authors.

Larissa Girardi SangoiRibeirao Preto Medical School, Department of Medical Imaging, Hematology and Clinical Oncology, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.

Joel Del Bel PáduaRibeirao Preto Medical School, Department of Pathology and Forensic Medicine, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.

Mateus de Andrade HernandesRibeirao Preto Medical School, Department of Medical Imaging, Hematology and Clinical Oncology, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.

Marcello Henrique Nogueira-BarbosaRibeirao Preto Medical School, Department of Medical Imaging, Hematology and Clinical Oncology, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.

Leonor Garbin SavareseRibeirao Preto Medical School, Department of Medical Imaging, Hematology and Clinical Oncology, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelioid hemangioma is a rare, low-grade vascular tumor defined by epithelioid endothelial differentiation. It has no pathognomonic clinical, laboratory, or imaging features, and its inconsistent nomenclature has historically complicated diagnosis. Although bone involvement is frequent and most lesions behave benignly, some demonstrate local aggressiveness or multifocal spread. We report a unique case of widespread bone lesions exhibiting a "button sequestrum" pattern, previously not described in epithelioid hemangioma. Pathologically, button sequestrum comprises a central island of devitalized bone surrounded by a lucent zone of granulation tissue, a finding that usually narrows the differential diagnosis. Recognizing this presentation broadens the known imaging spectrum of epithelioid hemangioma.

Indexed as

Bone tumorButton sequestrumEpithelioid hemangiomaMultifocal lesionsRadiology

Identifiers

PMID40821377

DOI10.1016/j.radcr.2025.06.121

PMCPMC12355506

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