Evidence map›Paper›PMID 40821276›Full record

ArticleCureus2025

Isolated Gamma-Glutamyl Transferase Elevation in an Asymptomatic Adolescent: An Unusual Presentation of Focal Nodular Hyperplasia.

Manuel Lima Ferreira, Teresa Cachada Baptista, Diana Alba, Ana Reis

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manuel Lima FerreiraDepartment of Pediatrics and Neonatology, Unidade Local de Saúde Tâmega e Sousa, Penafiel, PRT.
Teresa Cachada BaptistaDepartment of Pediatrics and Neonatology, Unidade Local de Saúde Tâmega e Sousa, Penafiel, PRT.
Diana AlbaDepartment of Pediatrics and Neonatology, Unidade Local de Saúde Tâmega e Sousa, Penafiel, PRT.
Ana ReisDepartment of Pediatrics and Neonatology, Unidade Local de Saúde Tâmega e Sousa, Penafiel, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incidental liver lesions (ILLs) in children are increasingly being identified due to the widespread use of imaging techniques. Focal nodular hyperplasia (FNH) is relatively rare in pediatric age, typically diagnosed based on characteristic imaging findings. We report the case of a 16-year-old asymptomatic female patient with persistent isolated elevation of gamma-glutamyl transferase (GGT), identified during routine evaluation. Further imaging, including abdominal ultrasound and magnetic resonance imaging with hepatocyte-specific contrast agent, revealed an ILL consistent with FNH, despite the absence of a classical central scar. The adolescent remained asymptomatic, and conservative follow-up was decided. This case highlights the diagnostic relevance of isolated GGT elevation as a potential indicator of FNH.

Indexed as

focal nodular hyperplasiagamma-glutamyl transferaseincidental liver lesionmagnetic resonance imagingpediatrics

Identifiers

PMID40821276
PMCPMC12355200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.