Evidence map›Paper›PMID 40821232›Full record

ArticleCureus2025

Comparing the Effectiveness of 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes: A Double-Blind Randomized Controlled Trial Among Medical Students in Southern Vietnam.

Do T Thao, Yen H Nguyen Thi, Duy H Le Nguyen, Anh T Dang The, Cuong P Tru Nguyen, Vy T Nguyen, Uyen N Quach, Loc T Truong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Do T ThaoOral Pathology and Periodontology Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Yen H Nguyen ThiMicrobiology Department, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Duy H Le NguyenDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Anh T Dang TheDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Cuong P Tru NguyenDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Vy T NguyenDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Uyen N QuachDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Loc T TruongDentistry Department, Faculty of Odonto-Stomatology, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDental plaque and gingivitis are prevalent conditions that can be controlled using antimicrobial mouthwashes. AIM AND

designThis double-blind, randomized controlled clinical trial aims to compare the effectiveness of 0.12% chlorhexidine (CHX) and silver nanoparticles (AgNPs) mouthwashes in managing dental plaque, gingivitis, microbial counts, and saliva pH. MATERIALS AND

methodsA total of 95 medical students were randomly divided into three groups: Group I (control group), 0.9% sodium chloride; Group II, 0.12% CHX mouthwash; and Group III, AgNPs mouthwash. Clinical parameters evaluated on the baseline and 21stday included the gingival index, Quigley-Hein plaque index (QHI), microbial counts, and saliva pH. The analysis of variance (ANOVA), Tukey post-hoc test, and paired t-tests were implemented.

resultsThe QHI in Group II decreased from 2.66 ± 0.75 to 1.97 ± 0.61 after 21 days (p < 0.001). Specifically for the QHI, there is a statistically significant difference between Group II and Group III, while there is no statistically significant difference when comparing the two groups in other clinical indices, and both groups showed a noticeable improvement after 21 days of use.

conclusionsBoth 0.12% CHX and AgNPs mouthwashes are appropriate alternative options for daily oral hygiene. However, CHX mouthwash should still be prioritized for plaque control.

Indexed as

chlorhexidinedental plaquegingivitismouthwashpreventive dentistrysilver nanoparticles

Identifiers

PMID40821232
PMCPMC12351066

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.