ArticleCureus2025
Bisphosphonate-Induced Atypical Femoral Fractures in Pediatric Patients With Lipoprotein Receptor-Related Protein 5 (LRP5) Gene Mutation: A Case Report of Twin Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bisphosphonate treatment for secondary osteoporosis in children, youth, and young adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Bisphosphonate-Related Pathological Femoral Fracture in a Child with ACTG2-Related Intestinal Failure and Metabolic Bone Disease: A Case Report.Journal of orthopaedic case reports · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical femoral fractures (AFFs) are rare complications in children receiving bisphosphonate therapy for bone disorders. Early-onset osteoporosis in this population is often linked to monogenic bone diseases caused by genetic mutations. This study aims to highlight the risk of AFFs associated with bisphosphonate therapy in pediatrics and review the treatment approaches for these fractures. We report two cases of AFFs in nine-year-old identical twins with early-onset osteoporosis secondary to a lipoprotein receptor-related protein 5 (LRP5) gene mutation. Both had been receiving long-term zoledronic acid therapy. Each twin sustained a low-energy, left-side, transverse fracture of the proximal femoral shaft within a span of nine days. Radiological imaging revealed evidence of an impending fracture on the contralateral femur in both cases. The fractures were managed with intramedullary nailing using the Orthopediatrics Simple Locking IntraMedullary (SLIM
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