ArticleCureus2025
The Relationship Between Spinal Cord Atrophy and Cardiovascular Risk.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLower brain volume is associated with various cardiovascular (CV) risk factors, but less is known about the spinal cord (SC). Concomitant SC atrophy may contribute to motor weakness and slowness that are prominent features of frailty, known to increase mortality. The objectives of this study were to determine potential relations between SC size, age, individual CV risk factors, and overall CV risk. Methods and results: We retrospectively reviewed 121 patients (age 60 ± 13 years, 75.2% females) who were referred to our institution for magnetic resonance imaging (MRI) of the cervical SC. Patients with known degenerative neurological or congenital disease were excluded from review. CV risk factors were obtained from medical records, and the Atherosclerotic Cardiovascular Disease (ASCVD) risk score was calculated. Cross-sectional SC area (SCA) was traced on each slice of the C2-C6 cervical images with electronic calipers and averaged. Mean SCA was inversely correlated with age (r = -.19; p = .04) and creatinine level (r = -.20; p = .03), but not with height (r = .04; p = .69), weight (r = .03; p = .72), or body mass index (r = .02; p = .80). There was a stepwise decrease in SCA in patients without hypertension (HTN) or diabetes mellitus (DM) (n = 23) compared to those with only HTN (n = 55) (84.4 ± 9.4 mm
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