ArticleAmerican journal of translational research2025
Predictive value of NLR, PLR and MPVLR for recent major cardiovascular adverse events in elderly patients with heart failure.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the application value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume to lymphocyte ratio (MPVLR) levels in identifying recent major cardiovascular adverse events (MACE) in elderly patients with heart failure (HF).
methodA total of 103 elderly HF patients admitted to Suzhou Hospital affiliated to Anhui Medical University from January 2022 to February 2025 were selected as the model group, and 74 patients from the same period served as the external validation group. All patients were followed up for 3 months after treatment. Patients were categorized into a MACE group and a non-MACE group based on the occurrence of MACE. Clinical data and levels of NLR, PLR, and MPVLR, were compared between the two groups. Multivariate logistic regression analysis was conducted to identify the independent risk factors for recent MACE. A forest plot was drawn using Graphpad Prism 8.0 software. Predictive models were evaluated using receiver operating characteristic (ROC) curves and calibration curves.
resultsPatients in the MACE group were older and had a higher prevalence of diabetes compared to the non-MACE group. Levels of NLR, PLR, and MPVLR were significantly elevated in the MACE group. Multivariate logistic regression analysis identified NLR (
conclusionElevated levels of NLR, PLR, and MPVLR can serve as independent risk factors for assessing the risk of recent MACE in elderly HF patients. The combined predictive model demonstrates high accuracy and may assist in early risk stratification and personalized preventive strategies to reduce the risk of MACE.
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