Evidence map›Paper›PMID 40821095›Full record

ArticleAmerican journal of translational research2025

Construction and validation of a nomogram to identify risk of sleep disorders in gastrointestinal tumor patients undergoing chemotherapy.

Qian Cao, Guowei Zhu, Ruizhi Shen, Jikai Liu, Xiao Liang, Minmin Zhu, Hao Xi

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Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Qian CaoWuxi Medical School, Jiangnan University Wuxi 214000, Jiangsu, China.
Guowei ZhuWuxi Medical School, Jiangnan University Wuxi 214000, Jiangsu, China.
Ruizhi ShenDepartment of Anesthesiology and Pain Medicine, Jiangnan University Medical Center (Wuxi No. 2 People's Hospital, Wuxi Clinical College of Nantong University) Wuxi 214000, Jiangsu, China.
Jikai LiuWuxi Medical School, Jiangnan University Wuxi 214000, Jiangsu, China.
Xiao LiangDepartment of Anesthesiology and Pain Medicine, Jiangnan University Medical Center (Wuxi No. 2 People's Hospital, Wuxi Clinical College of Nantong University) Wuxi 214000, Jiangsu, China.
Minmin ZhuDepartment of Anesthesiology and Pain Medicine, Jiangnan University Medical Center (Wuxi No. 2 People's Hospital, Wuxi Clinical College of Nantong University) Wuxi 214000, Jiangsu, China.
Hao XiDepartment of Anesthesiology and Pain Medicine, Jiangnan University Medical Center (Wuxi No. 2 People's Hospital, Wuxi Clinical College of Nantong University) Wuxi 214000, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to identify risk factors for sleep disorders in gastrointestinal cancer patients undergoing chemotherapy and to construct a predictive nomogram model, validated both internally and externally.

methodsA prospective study was conducted (ChiCTR2400085854), involving 308 patients from Jiangnan University Affiliated Central Hospital (Oct 2023-Aug 2024) for model development. Sleep quality and symptom burden were assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Memorial Symptom Assessment Scale-Chinese version (MSAS-Ch). Independent risk factors were identified by multivariate logistic regression. A nomogram was constructed using R software and validated internally with 1000 bootstrap resamples and externally with 103 patients (Aug-Dec 2024). Model performance was evaluated by AUC, calibration curves, and decision curve analysis (DCA).

resultsThe incidence of sleep disorders was 53.8%. Significant influencing factors included longer disease duration, more severe depression, pain, fatigue, and diarrhea, as well as lower social support and physical activity (all

conclusionsSleep disorders are prevalent among gastrointestinal cancer patients undergoing chemotherapy. The developed nomogram demonstrates high predictive accuracy and is a practical tool to identify high-risk patients.

Indexed as

chemotherapyGastrointestinal cancernomogramprediction modelsleep disorders

Identifiers

PMID40821095
PMCPMC12351578

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