ArticleAmerican journal of translational research2025
Combined corticosteroid therapy enhances outcomes of endoscopic sinus surgery in chronic rhinosinusitis with nasal polyps: a prospective cohort study.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic sinus surgery combined with nasal corticosteroids and surgery alone for chronic rhinosinusitis with nasal polyps: a meta-analysis.BMC surgery · 2026Pooled it
- A Novel Device to Improve the Tolerability of Intranasal Corticosteroid Sprays for Allergic Rhinitis and Postoperative Chronic Rhinosinusitis: A Crossover Trial.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Trial
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the efficacy and safety of nasal endoscopic surgery combined with pharmacological therapy versus surgery alone for chronic rhinosinusitis with nasal polyps (CRSwNP).
methodsIn this prospective cohort study, 94 CRSwNP patients were randomized into two groups: a drug combination group (surgery + budesonide suspension, n=47) and a surgery-alone group (n=47). Outcomes were assessed at 1, 3, 6, 9, 12, and 18 months postoperatively, including Lund-Kennedy scores, SNOT-22 (with subdomain analysis), inflammatory biomarkers (blood/tissue eosinophils, IL-4, IL-5, IgE), nasal ventilation parameters (NMCA, DCAN), mucociliary clearance rate, and olfactory function scores.
resultsCompared with surgery alone, the combination group showed significantly lower Lund-Kennedy scores at 6 months (P=0.036), 12 months (P<0.010), and 18 months (P<0.010). SNOT-22 subdomain analysis revealed greater improvements in nasal symptoms at postoperative 3 months (P<0.010) and sleep dysfunction at postoperative 1 month (3.12±0.58 vs. 3.73±0.63, P=0.007). The recurrence rate was significantly lower in the combination group (2.13% vs. 8.51%, P<0.010). Inflammatory biomarkers showed greater suppression in the combination group, including a 41.3% reduction in IL-5 at postoperative 12 months (P<0.010) and a sustained decrease in peripheral blood eosinophil percentage at postoperative 18 months (P<0.010). Nasal ventilation improved at postoperative 12 months (NMCA, P<0.010). Mucociliary clearance was significantly enhanced in the combination group at postoperative 12 months (5.210±0.360 vs. 4.812±0.334 mm/min, P<0.011). Olfactory function scores were significantly better at 6 months (P<0.012) and 12 months (P<0.010).
conclusionCompared to surgery alone, combining corticosteroids with surgery more effectively suppresses type-2 inflammation, improves multidimensional symptom control (particularly nasal and sleep domains), enhances nasal function, and reduces recurrence. This combination strategy offers a more comprehensive strategy for CRSwNP management.
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