Assessing the association of IL-17A and IL-17F polymorphisms with osteoarthritis risk: a systematic review and meta-analysis.

Ran Xu, Xin Liu, Fan Zhou, Jie Liu, Dunyao Bai

Abstract read

In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ran XuCollege of Nursing, Chengdu University of Traditional Chinese Medicine No. 1166, Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan, China.

Xin LiuDepartment of Orthopedics, Second Affiliated Hospital of The Army Medical University (Xinqiao Hospital) No. 83 Xinqiao Main Street, Shapingba District, Chongqing 400037, China.

Fan ZhouDepartment of Medical Biomolecular, Puren Hospital Affiliated to Wuhan University of Science and Technology No. 1 Benxi Street, Wuhan 430081, Hubei, China.

Jie LiuDepartment of Orthopedics, Second Affiliated Hospital of The Army Medical University (Xinqiao Hospital) No. 83 Xinqiao Main Street, Shapingba District, Chongqing 400037, China.

Dunyao BaiDepartment of Medical Biomolecular, Puren Hospital Affiliated to Wuhan University of Science and Technology No. 1 Benxi Street, Wuhan 430081, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a systematic review and meta-analysis to clarify the relationship between these gene polymorphisms and Osteoarthritis (OA) risk. We searched electronic databases and found 736 related reports, five of which were ultimately included in the study. The articles ranged from 2014 to 2019 and included both Asian and Caucasian populations. Genotypes were categorized into TT, TC, and CC across case and control groups. The meta-analysis of interleukin-17A (IL-17A; rs2275913) showed no significant correlation with OA in the overall human population's allele model, codominance model, dominance model, and recessive model (P=0.97, 0.94, 0.77, 0.80, 0.85). Ethnic subgroup analysis showed no association between the Asian or Caucasian populations' IL-17A gene and OA. However, the meta-analysis of interleukin-17F (IL-17F; rs763780) showed that this gene is related to OA in the overall population and each single nucleotide polymorphism (SNP) genetic model (

Indexed as

gene polymorphismsIL-17A geneIL-17F genemeta-analysisOsteoarthritis

Identifiers

PMID40821073

DOI10.62347/SUPA1847

PMCPMC12351623

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.