Evidence map›Paper›PMID 40821057›Full record

ArticleAmerican journal of translational research2025

Early risk identification for recurrent wheezing in children with respiratory syncytial virus infections.

Ying Wang, Yalin Shi, Lijuan Wang

Abstract read
In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying WangDepartment of Pediatric Cardiovascular and Respiratory Medicine, Xianyang Rainbow Hospital Xianyang 712000, Shaanxi, China.
Yalin ShiDepartment of Pediatric Respiratory Medicine, Xianyang Rainbow Hospital Xianyang 712000, Shaanxi, China.
Lijuan WangDepartment of Pediatric Respiratory Medicine, Xianyang Rainbow Hospital Xianyang 712000, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the predictive value of peripheral blood eosinophil (EOS) count and nasopharyngeal microbiota for recurrent wheezing in children following respiratory syncytial virus (RSV) lower respiratory tract infections.

methodsThis retrospective study included 614 children with RSV infection and an external validation cohort of 164 children. Clinical data, hematological parameters, and nasopharyngeal microbiota profiles were collected. Logistic regression was used to identify independent predictors of recurrent wheezing. A predictive model was developed and validated using receiver operating characteristic (ROC) and calibration curves.

resultsPeripheral blood EOS count, serum 25(OH)D and IgM levels, and nasopharyngeal bacterial colonization (notably

conclusionPeripheral blood EOS count and nasopharyngeal microbiota composition are critical predictors of recurrent wheezing following RSV infection. The predictive model may aid in early risk stratification and personalized intervention to prevent recurrent wheezing in pediatric patients.

Indexed as

childreneosinophilsnasopharyngeal microbiotapredictive modelrecurrent wheezingRespiratory syncytial virus

Identifiers

PMID40821057
PMCPMC12351585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.