Evidence map›Paper›PMID 40821038›Full record

ArticleAmerican journal of translational research2025

Epidemiologic characteristics of immunoglobulin M antibodies in lower respiratory tract infection pathogens of children: association with severe pneumonia in Chengdu city from 2019 to 2023.

Jinghua Ye, Mei Cha, Haibo Yao, Qin Zhang, Mengjun Luo, Yiting Du, Yuanhu Lu, Jinyan Chen, Yinghong Fan, Dongmei Xiao and 3 more

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Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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13 authors.

Jinghua YeDepartment of Public Health, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Mei ChaDepartment of Public Health, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Haibo YaoDepartment of Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Qin ZhangDepartment of Public Health, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Mengjun LuoClinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Yiting DuDepartment of Emergency, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Yuanhu LuInformation Center, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Jinyan ChenDepartment of Public Health, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Yinghong FanDepartment of Respiratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Dongmei XiaoDepartment of Hospital Infection Control, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University) Chengdu 610200, Sichuan, China.
Yixiao PengDepartment of Public Health, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu 611731, Sichuan, China.
Yanyin LiuDepartment of Public Health, The Fourth People's Hospital of Sichuan Province Chengdu 611731, Sichuan, China.
Liangyin DengInternal Medicine, Peng Zrou Harmonious Hospital Chengdu 611731, Sichuan, China.

Funding

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6 · The paper itself

Abstract

objectiveTo analyze the epidemiologic characteristics of serum immunoglobulin M (IgM) antibody aming six pathogens in children with acute lower respiratory tract infections (LRTI) and its association with severe pneumonia, thereby providing a basis for clinical diagnosis and treatment.

methodsA total of 25,693 children with lower respiratory tract infections who were hospitalized in the Department of Respiratory Medicine at Chengdu Women's and Children's Central Hospital from 2019 to 2023 were included and retrospectively analyzed in the study. The epidemiologic characteristics of serum IgM antibodies for six LRTI pathogens in the enrolled children were analyzed. Logistic regression analysis was conducted to identify risk factors for severe pneumonia.

resultsThe IgM positive detection rate among the six pathogens was 30.26%. In addition, the IgM positive detention rates among Mycoplasma pneumoniae (MP), Parainfluenza virus (PVI) and Influenza B virus (IFV-B) of female children were higher than those of male children (P < 0.05); Children who were younger than 1 year oldshowed the lowest IgM positive detention rates of MP and IFV-B (P < 0.05). The positivity rates of IgM antibodies for MP, IFV-B, PIV, and Respiratory syncytial virus (RSV) markedly varied across different lower respiratory tract infections (P < 0.001; P = 0.007; P = 0.004; P < 0.001). The IgM positive detection rate of two or more pathogens before COVID-19 pandemic were higher in comparison to those post COVID-19 (P < 0.05). Compared to the non-severe group, children with severe pneumonia showed a relatively lower detection rate of MP but a significantly higher detection rate of RSV. The results of multiple logistic regression analysis suggested that age and gender were independent influencing factors for severe pneumonia, with an area under the Receiver Operating Characteristics curve of 0.727.

conclusionIn Chengdu city, the positivity rates of IgM antibodies for LRTI pathogens in children exhibited seasonal, age-related, and diagnostic category characteristics-related variations. Severe pneumonia cases were characterized by RSV infection and younger age. Clinicians should take epidemiologic features into consideration to optimize their diagnostic and therapeutic strategies.

Indexed as

ChildrenIgM antibodieslower respiratory tract infectionpathogenssevere pneumonia

Identifiers

PMID40821038
PMCPMC12351617

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