ArticleAmerican journal of translational research2025
Association of D-dimer, platelet-activating factor, and soluble vascular endothelial growth factor receptor 1 levels with disease severity and prognosis in gestational hypertension.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the associations of D-dimer (D-D), platelet-activating factor (PAF), and soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels with disease severity and prognosis in hypertensive disorders complicating pregnancy (HDCP).
methodsA total of 138 HDCP patients were categorized as the gestational hypertension (GH, n = 62), preeclampsia (PE, n = 45), and severe preeclampsia (SPE, n = 31) groups. Fifty healthy pregnant women served as controls. Plasma D-D and serum PAF and sVEGFR-1 levels were measured and compared. ROC curves assessed their diagnostic and prognostic value. Based on neonatal Apgar score <7 or grade III amniotic fluid contamination, patients were divided into good (n = 73) and poor (n = 65) prognosis groups.
resultsD-D, PAF, and sVEGFR-1 levels increased with disease severity (all P<0.05). The AUCs for diagnosing HDCP severity were 0.893 (D-D), 0.889 (PAF), 0.825 (sVEGFR-1), and 0.944 (combined). Multivariate logistic regression identified D-D, PAF, sVEGFR-1, and 24h RPO as independent prognostic factors (all P<0.05). Combined AUC for prognosis prediction was 0.883.
conclusionElevated D-D, PAF, and sVEGFR-1 levels are closely associated with HDCP severity and prognosis, offering high diagnostic and predictive value.
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