ArticleAmerican journal of translational research2025
Application value of metagenomic next-generation sequencing of bronchoalveolar lavage fluid in pathogen detection and diagnostic efficiency of acute exacerbation of bronchiectasis.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Precision diagnostics in bronchiectasis: current advances in imaging, microbiology, biomarkers, and digital health.Frontiers in medicine · 2026Review
- Phage characterization analysis in respiratory samples from infected patients based on metagenomic next-generation sequencing.Frontiers in cellular and infection microbiology · 2026Article
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4 authors.
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Abstract
objectiveTo investigate pathogen detection performance and diagnostic efficacy of bronchoalveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) in patients with acute exacerbation of bronchiectasis (AE-bronchiectasis).
methodsA retrospective analysis was conducted on 78 patients with AE-bronchiectasis admitted to the First Affiliated Hospital of Guangxi Medical University from March 2020 to December 2023. Pathogen detection rates and diagnostic efficacy of conventional culture detection and BALF mNGS group were compared. Seventy-six patients diagnosed as positive by the gold standard were further stratified by bronchiectasis severity index (BSI) into mild-to-moderate and severe groups to analyze differences in pathogen profiles.
resultsCompared to conventional culture, mNGS showed significantly higher detection rates for bacteria, fungi, and mycobacteria (all P<0.05), notably
conclusionBALF mNGS demonstrates clear advantages over conventional methods in pathogen detection for AE-bronchiectasis, offering significantly better detection rates and diagnostic efficiency.
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