SynthesisFrontiers in psychiatry2025
Physiological attunement and flourishing: understanding the influence of relationships on health.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Molecules to Meaning: Integrating Neuropeptides, Sociostasis, and Hormesis in the Brain-Heart Axis.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Flourishing can be defined as the experience of life going well, a combination of feeling good and functioning effectively. High-quality relationships are essential to flourishing and long-term health. Physiological interdependence-such as synchronization of autonomic and endocrine systems-has been proposed as a mechanism supporting emotion regulation and social bonding. Methods: This scoping review maps the existing literature on physiological attunement in adult dyadic relationships. The review protocol was registered on the Open Science Framework (https://osf.io/295ge/) and followed JBI methodology for scoping reviews. PubMed and Scopus databases were searched. Eligible studies were original, quantitative, peer-reviewed articles published in English that examined physiological attunement in adult human dyads. Two reviewers independently screened and selected the studies. Results: A total of 62 studies were included. Attunement was observed in romantic partners, friends, strangers, and groups, involving heart rate, heart rate variability, skin conductance, respiration, cortisol, and alpha-amylase. Physiological attunement was shaped by relational context, emotional tone, individual traits (e.g., empathy, attachment style), and interaction features (e.g., touch, conflict, cooperation). While often linked to satisfaction, intimacy, and co-regulation, synchrony also appeared in distress contexts, sometimes reflecting stress contagion or co-dysregulation. Conclusion: Physiological attunement appears to be a context-sensitive process that may support or hinder wellbeing. It may represent a key biobehavioral pathway linking relationships to flourishing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.