ArticleFrontiers in psychiatry2025
Association of brain-derived neurotrophic factor levels at different trimesters and new-onset depressive symptom in the third trimester among pregnant women: a longitudinal study.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Serum BDNF, VEGF, and EGF Levels in Pregnant Women with Anxiety and Depression.International journal of molecular sciences · 2026Article
- A 'Standard of Care PLUS' Model for Preterm Birth Prevention: Integrating Nutrient and Gene Variant Analysis with Targeted Interventions.Journal of personalized medicine · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Accumulating evidence e suggests that brain-derived neurotrophic factor (BDNF) may play a role in the development of depression. However, changes in serum BDNF during distinct gestational periods and their association with prenatal depression remain unclear. Objectives: To investigate the change of serum BDNF in the first, second and third trimester and their longitudinal association with depressive symptoms in the third trimester. Methods: Depressive symptoms in the first and third trimester were assessed using the Patient Health Questionnaire-9 (PHQ-9). An automatic biochemical analyzer was used to detect serum BDNF levels based on enzyme-linked immunosorbent assay (ELISA) in the first, second and third trimester. Linear regression, binary and multivariable logistic regression model were used to analyze the association between BDNF levels during different pregnancy with PHQ-9 score and depressive symptoms in the third trimester. Results: The mean age of 500 pregnant women included in this study was (26.8 ± 2.3) years in the first trimester. At the third trimester, a total of 72 pregnant women (14.4%) developed depressive symptoms. The average serum BDNF level was highest in the first trimester and lowest in the second trimester. Each 1 pg/mL increase of first trimester BDNF was associated with a 43% decrease in the risk of prenatal depressive symptoms (95% confidence interval [95% Conclusion: Overall, serum BDNF levels in the first, second, and third trimester were significantly associated with decreased PHQ-9 score and reduced risk of prenatal depressive symptoms. Serum BDNF shows promise as a predictive biomarker for antenatal depressive symptoms across all trimesters.
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