ArticleFrontiers in psychiatry2025
Influence of comorbid anxiety and depression disorder on cognition in older adults with epilepsy.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Plasma neurofilament light chain: A novel biomarker of neuroaxonal injury associated with depressive symptoms in epilepsy.Epilepsia · 2026Article
- Affective and Cognitive Vulnerability Under Chronic Stress: Insights From Patients With Left Temporal Lobe Epilepsy and Caregivers.Actas espanolas de psiquiatria · 2026Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to investigate the association of comorbid depression and anxiety with cognitive function in older adults with epilepsy. Methods: A cross-sectional analysis was conducted on 406 older adults (≥65 years) diagnosed with epilepsy between January 2019 and December 2020. Depressive and anxious symptoms were measured using the Hospital Anxiety and Depression Scale (HADS), while cognitive impairment was assessed with the Montreal Cognitive Assessment Test (MoCA). Multivariate linear regression models were used to examine associations between cognitive impairment and anxiety/depression symptoms, adjusting for potential confounders. Results: Of the 406 adults, 218 (53.7%) showed cognitive impairment. Adults with depression (70.2% vs. 51.0%, Conclusion: Anxiety and depression are significantly associated with cognitive impairment in older adults with epilepsy. Early screening and management of these psychiatric conditions are essential to reduce cognitive decline and enhance patient outcomes.
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