ArticleFrontiers in psychiatry2025
Beyond the beats: exploring the link between blood pressure fluctuations with anxiety, depression, and sleep.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Blood pressure variability (BPV) is a marker of vascular and autonomic regulation, and emerging evidence links BPV with anxiety and depression. Limited research has explored central BPV, and secondly whether sleep modulates the association between BPV with anxiety and depression. Study design: Eighty-eight adults from clinical and community settings underwent 24-hour ambulatory blood pressure monitoring to assess central and brachial BPV, including augmentation index (AIx), mean arterial pressure (MAP), and pulse pressure (PP). Psychological symptoms were evaluated using the Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire (PHQ-9), and Sleep Condition Indicator (SCI). Correlation and regression analyses were conducted, adjusting for age and gender. Mediation analyses explored the role of sleep disturbances in BPV-mood relationships. Results: Higher central BPV was associated with lower anxiety symptom severity, for somatic and cognitive symptoms (e.g., trouble relaxing: rs = -0.28, p < 0.01), whereas brachial BPV showed minimal associations. No significant relationships emerged between BPV and depressive symptoms after adjustment. AIx demonstrated significant negative associations with sleep-related issues, with stronger effects seen when adjusting for age and gender (β = -0.04, p < 0.01). Mediation analysis revealed sleep-related issues partially mediated the BPV-anxiety relationship. Discussion: Findings suggest that central BPV is more strongly associated with cognitive and somatic anxiety symptoms than depressive symptoms, with sleep disturbances potentially mediating this relationship. These results support BPV's role in autonomic dysfunction, emphasizing the need for longitudinal research to clarify its role in mental health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.