Evidence map›Paper›PMID 40820981›Full record

ArticleJournal of the American Heart Association2025

Activation of Chemokine (C-C Motif) Receptor 1 Modulates α

Xianlong Gao, Elizabeth A Cook, Sadia N Boshra, Ololade R Ogunsina, Matthias Majetschak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xianlong GaoDepartment of Surgery University of South Florida Morsani College of Medicine Tampa FL USA.ORCID 0000-0003-0261-2628
Elizabeth A CookDepartment of Surgery University of South Florida Morsani College of Medicine Tampa FL USA.ORCID 0009-0007-0246-5361
Sadia N BoshraDepartment of Surgery University of South Florida Morsani College of Medicine Tampa FL USA.ORCID 0009-0002-3013-3245
Ololade R OgunsinaDepartment of Surgery University of South Florida Morsani College of Medicine Tampa FL USA.
Matthias MajetschakDepartment of Surgery University of South Florida Morsani College of Medicine Tampa FL USA.ORCID 0000-0002-4086-0887

Funding

Regulation of vascular function after traumatic-hemorrhagic shock and during inflammationR35GM152056 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Matthias Majetschak · 2024 to 2026
$938k
Surgeon-Scientist Research Training in Injury Pathobiology and Outcomes In Critical IllnessT32GM144274 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI PAUL C KUO, Matthias Majetschak · 2023 to 2026
$635k
NIGMS NIH HHS R35 GM152056NIGMS NIH HHS T32 GM144274
6 · The paper itself

Abstract

backgroundWe reported previously that α METHODS AND

resultsBioluminescence resonance energy transfer suggested that the receptors can form hetero-oligomeric complexes. Activation of CCR1 with CCL23 (chemokine [C-C motif] ligand 23) increased the efficacy of aVP (arginine vasopressin)-stimulated AVPR1A and reduced the efficacy of phenylephrine-stimulated α

conclusionsOur findings suggest that CCR1 within functional heteromeric complexes with α

Indexed as

Muscle, Smooth, VascularMyocytes, Smooth MuscleReceptors, Adrenergic, alpha-1Receptors, CCR1Receptors, VasopressinSignal TransductionAdrenergic alpha-1 Receptor AgonistsArginine VasopressinCells, CulturedChemokines, CCGTP-Binding Protein alpha Subunits, Gq-G11HumansPhenylephrineVasoconstrictionADRA1B protein, humanAdrenergic alpha-1 Receptor AgonistsArginine VasopressinAVPR1A protein, humanCCR1 protein, humanChemokines, CCGTP-Binding Protein alpha Subunits, Gq-G11PhenylephrineReceptors, Adrenergic, alpha-1Receptors, CCR1Receptors, Vasopressinarginine vasopressin receptor 1Achemokine (C‐C motif) receptor 1G protein‐coupled receptor heteromersvascular smooth muscle contractionα1B‐adrenoceptor

Identifiers

PMID40820981
PMCPMC12553424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.