Evidence map›Paper›PMID 40820881›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury.

Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role ofInfection and drug resistance · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Renjie CaoGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Tingting ZhaoGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Ying WangSun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510006, China.
Shaofei SongGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Yuan LiGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Mengling HouGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Yanxin ZhangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Sengpeng WongGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Siqi WangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Yuran WangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Hong PengCenter of Hepato-Pancreato-biliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510006, China.
Min HuangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.
Yiming JiangGuangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, 510006, China.ORCID https://orcid.org/0000-0002-4894-177X

Funding

Fundamental Research Funds for the Central Universities, Sun Yat-Sen University 22qntd4502Guangdong Basic and Applied Basic Research Foundation 2019A1515010247Guangdong Provincial Key Laboratory of Construction Foundation 2020B1212060034Guangzhou Basic and Applied Basic Research Foundation 202102020717Guangzhou Basic and Applied Basic Research Foundation 2024A04J9901Higher Education Discipline Innovation Project B16047National Natural Science Foundation of China 82003840National Natural Science Foundation of China 82173881Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0502300
6 · The paper itself

Abstract

Macrophage proinflammatory hyperactivation drives the pathogenesis of acute liver injury, a common complication of sepsis. The role of the nuclear receptor constitutive androstane receptor (CAR) in endotoxin-induced liver injury remains unclear. Here, this study reports that CAR is highly expressed in human and murine macrophages. CAR activation markedly attenuated endotoxin-induced liver damage, alleviating hepatocyte death and hepatic inflammation. Macrophage-hepatocyte coculture confirmed that CAR inhibited inflammation through macrophage crosstalk. CAR-mediated hepatoprotection and anti-inflammatory effects are absent in AAV8-F4/80-shCar-treated mice, confirming the essential role of CAR in macrophages. Mechanistically, CAR is found to interact with Tlr4, and the suppressive effects of CAR on TLR4 are proven in Tlr4

Indexed as

EndotoxemiaImmunity, InnateMacrophagesReceptors, Cytoplasmic and NuclearToll-Like Receptor 4AnimalsConstitutive Androstane ReceptorHumansLipopolysaccharidesLiverMaleMiceMice, Inbred C57BLMice, KnockoutRAW 264.7 CellsSignal TransductionConstitutive Androstane ReceptorLipopolysaccharidesReceptors, Cytoplasmic and NuclearTlr4 protein, mouseToll-Like Receptor 4constitutive androstane receptorendotoxemialiver injurytoll‐like receptor 4

Identifiers

PMID40820881
PMCPMC12622418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.