Evidence map›Paper›PMID 40820834›Full record

ArticleHaematologica2026

Metallothionein 1 mediates growth and survival of

Patricia A Colom Díaz, Jayna J Mistry, Kira A Young, Chih-Hsing Chou, Nathan Boyer, Ross L Levine, Nathan Salomonis, H Leighton Grimes, Jennifer J Trowbridge

Abstract read
In one paragraph

Article in Haematologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patricia A Colom DíazThe Jackson Laboratory, Bar Harbor, ME.
Jayna J MistryThe Jackson Laboratory, Bar Harbor, ME.
Kira A YoungThe Jackson Laboratory, Bar Harbor, ME.
Chih-Hsing ChouDivision of Immunobiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH.
Nathan BoyerThe Jackson Laboratory, Bar Harbor, ME.
Ross L LevineMemorial Sloan Kettering Cancer Center, New York, NY.
Nathan SalomonisDivision of Biomedical Informatics, CCHMC, Cincinnati, OH, USA; Division of Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, OH.
H Leighton GrimesDivision of Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, OH.
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME. Jennifer.trowbridge@jax.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mechanisms of granulocyte homeostasisR01HL122661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI H. LEIGHTON GRIMES, Nathan G. Salomonis · 2015 to 2026
$5.3M
A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesisRC2DK122376 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON · 2020 to 2024
$5.3M
Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle AgeR01DK118072 · NIDDK · JACKSON LABORATORY · PI Jennifer Jean Trowbridge · 2018 to 2026
$4.2M
Modeling myelodysplasiaR01CA253981 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON, HALENE, STEPHANIE · 2021 to 2025
$2.9M
Inflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem CellsU01AG077925 · NIA · JACKSON LABORATORY · PI LEVINE, ROSS L, TROWBRIDGE, JENNIFER JEAN · 2021 to 2025
$2.9M
Towards an inclusive genomic risk classification for acute myeloid leukemia (AML)R01CA284595 · NCI · OHIO STATE UNIVERSITY · PI Ann-Kathrin Eisfeld, H. LEIGHTON GRIMES · 2023 to 2026
$2.6M
Discovery of Aging-Associated Mechanisms Causing Expansion and Progression of Clonal Hematopoiesis of Indeterminant Potential (CHIP)R01AG069010 · NIA · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2020 to 2024
$2.4M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA253981NCI NIH HHS R01 CA284595NHLBI NIH HHS R01 HL122661NIA NIH HHS R01 AG069010NIA NIH HHS U01 AG077925NIDDK NIH HHS R01 DK118072NIDDK NIH HHS RC2 DK122376
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40820834
PMCPMC12775785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.