Evidence map›Paper›PMID 40820826›Full record

ArticleOncoimmunology2025

CyTOF profiling of bone marrow immune dynamics across myeloma stages.

Dana Cholujova, Gabor Beke, Lubos Klucar, Lubos Drgona, Zuzana Valuskova, Merav Leiba, Efstathios Kastritis, David M Dorfman, Kenneth C Anderson, Jana Jakubikova

Abstract read
In one paragraph

Article in Oncoimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dana CholujovaDepartment of Tumor Immunology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Gabor BekeInstitute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia.
Lubos KlucarInstitute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovakia.
Lubos DrgonaDepartment of Oncohematology, Comenius University and National Cancer Institute, Bratislava, Slovakia.
Zuzana ValuskovaDepartment of Tumor Immunology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Merav LeibaFaculty of Health Science, Assuta Ashdod University Hospital, Ben-Gurion University of the Negev, Ashdod, Israel.
Efstathios KastritisDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
David M DorfmanDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Kenneth C AndersonDana Farber Cancer Institute, Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Boston, MA, USA.
Jana JakubikovaDepartment of Tumor Immunology, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.ORCID 0000-0003-2593-569X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) orchestrates a profound disruption of immune balance within the bone marrow (BM) microenvironment, driving disease progression and therapeutic resistance. To better understand these complex immune dynamics, we used high-dimensional mass cytometry (CyTOF) profiling to comprehensively characterize the immune landscape of the BM across different stages of myeloma progression, including MGUS (

Indexed as

Bone MarrowMultiple MyelomaAgedDisease ProgressionFemaleFlow CytometryHumansMaleMiddle AgedTumor MicroenvironmentMass cytometrymultiple myelomatumor immune microenvironment

Identifiers

PMID40820826
PMCPMC12363513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.