ArticleCNS neuroscience & therapeutics2025
Hypothalamic Orexin Projections to the Hippocampal CA1 Region Alleviate Cognitive and Synaptic Plasticity Impairments Induced by Blue Light Exposure.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Small molecule orexin agonist ROXA-47 enhances learning and memory in mice.Pharmacology, biochemistry, and behavior · 2026Article
- Hypothalamic Orexin Projections to the Hippocampal CA1 Region Alleviate Cognitive and Synaptic Plasticity Impairments Induced by Blue Light Exposure.CNS neuroscience & therapeutics · 2025Article
- Research progress on the neural mechanism of light therapy improving cognitive function in depression: from retinal projections to neuroplasticity.Frontiers in neurologyReview
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
objectivesExposure to blue light emitted from electronic devices has been shown to impair cognitive performance; however, the mechanisms underlying these deleterious effects remain poorly understood. Orexin neurons in the hypothalamus, which play a key role in modulating cognitive processes and synaptic plasticity, project directly to the hippocampus, a brain region critical for learning and memory. Therefore, our study provides novel insights into the neural mechanisms underlying blue light-related cognitive dysfunction. METHODS AND
resultsIn this study, we evaluated cognitive impairments in mice subjected to 21 days of blue light exposure using open-field, novel object recognition, and Morris water maze tests. Electrophysiological recordings and Golgi staining revealed that synaptic plasticity was significantly impaired in blue light-exposed mice. The results of biochemical experiments indicated that the expression of Orexin-A, along with the synaptic plasticity-related factors PSD-95 and SYN-1, was downregulated at both the protein and gene levels in the hippocampus of mice following blue light exposure. Furthermore, retrograde tracing combined with immunofluorescence staining showed that hypothalamic orexin neurons projected to the hippocampus, and that CTb-labeled orexin neurons were significantly activated in the hypothalamus (c-FOS
conclusionsThese findings suggest that the hypothalamic orexin projections to the hippocampal CA1 region alleviate cognitive and synaptic plasticity impairments induced by blue light exposure.
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Registered trials
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