Evidence map›Paper›PMID 40820466›Full record

ArticleAddiction biology2025

Inflexible Orbitofrontal Cortex Functional Connectivity From Rest to Acute Stress in Alcohol Use Disorder.

Dylan E Kirsch, Tiffany C Ho, Kate M Wassum, Lara A Ray, Erica N Grodin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dylan E KirschDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-9935-9635
Tiffany C HoDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Kate M WassumDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-5734-9444
Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-5528-4918

Funding

Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
The effects of stress on decision-making in alcohol use disorder: A translational approachR21AA030643 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2023 to 2024
$410k
A clinical neuroscience approach to understand stress coping in alcohol use disorderF32AA031425 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIRSCH, DYLAN E · 2024 to 2024
$32k
NIAAA NIH HHS F32AA031425NIAAA NIH HHS K01AA029712NIAAA NIH HHS K24AA025704NIAAA NIH HHS R21AA030643
6 · The paper itself

Abstract

Adaptive stress coping is often impaired in individuals with alcohol use disorder (AUD). This process relies on neurocircuitry involved in emotional and behavioural regulation, particularly the ventromedial PFC (vmPFC) and orbitofrontal cortex (OFC), along with limbic and ventral striatal regions (e.g., amygdala, hippocampus and nucleus accumbens). These systems are highly sensitive to the neurotoxic effects of alcohol, which may disrupt their ability to flexibly adapt in response to acute stress. This study investigated state-dependent changes (termed 'flexibility') in vmPFC-limbic/striatal and OFC-limbic/striatal functional connectivity from rest to acute stress in individuals with AUD versus matched controls and examined associations with coping strategies. Twenty-four adults with AUD (age

Indexed as

AlcoholismPrefrontal CortexStress, PsychologicalAdaptation, PsychologicalAdultAmygdalaCase-Control StudiesFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysRestaddictionalcoholamygdalahippocampusprefrontal cortexresting‐state fMRIstress

Identifiers

PMID40820466
PMCPMC12358688

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.