Evidence map›Paper›PMID 40820429›Full record

ArticleCNS neuroscience & therapeutics2025

Optimal Stimulation Sites and Connectomes for GPi and STN-DBS in Cervical Dystonia.

Tao Xue, Youjia Qiu, Wei Tian, Hutao Xie, Shiying Fan, Houyou Fan, Minjia Xie, Ming Ye, Zhong Wang, Tongbo Ning and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tao XueDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Youjia QiuDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wei TianDepartment of Neurosurgery, Weihai Central Hospital, Weihai, China.
Hutao XieDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-3725-5085
Shiying FanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Houyou FanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-4420-3139
Minjia XieDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ming YeDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhong WangDepartment of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Tongbo NingDepartment of Neurosurgery, Weihai Central Hospital, Weihai, China.
Chunlei HanDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hua ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0009-0006-3833-3881
Anchao YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Lin SangDepartment of Neurosurgery, Beijing FengTai Hospital, Beijing, China.
Jurgen GermannKrembil Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Alexandre BoutetJoint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-6942-5195
Joseph TamDivision of Neurosurgery, Depatment of Surgery, University of Toronto, Toronto, Canada.
Andres M LozanoKrembil Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Fangang MengBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Yutong BaiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-5676-3811
Jianguo ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0009-0574

Funding

National Natural Science Foundation of China 82171442National Natural Science Foundation of China 82401713National Natural Science Foundation of China 82402252the Beijing Municipal Science & Technology Commission and Administrative Commission of Zhongguancun Science Park Z241100009024019the Postdoctoral Fellowship Program of CPSF GZC20231742
6 · The paper itself

Abstract

aimsTo map optimal stimulation targets (sweet spots) and neural networks for globus pallidus internus (GPi)- and subthalamic nucleus (STN)-deep brain stimulation (DBS) in cervical dystonia (CD), and compare their structural/functional connectivity profiles and predictive validity for clinical outcomes.

methodsRetrospective analysis of 76 stimulation settings from 38 CD patients across four centers. Volume of tissue activated was reconstructed; connectivity-based sweet spots were identified. Structural/functional connectivity models were developed using normative connectomes and validated externally. Clinical outcomes were assessed using validated scales.

resultsOptimal targets localized to the posterior ventral medial GPi and dorsolateral STN. The ideal probabilistic stimulation maps of STN-DBS exhibited predictive clinical improvement. Both targets showed beneficial connections to the motor cortex, with GPi-DBS negatively connected to the occipital lobe and STN-DBS positively connected to the premotor cortex and cerebellum. Functional connectivity patterns further highlighted shared and distinct regions linked to CD symptoms. Moreover, the structural and functional connectivity models predicted postoperative improvement through internal and external validation.

conclusionGPi- and STN-DBS engage distinct but overlapping networks in CD. Connectivity-based models robustly predict clinical improvement, offering tools for personalized targeting and programming. These findings clarify network mechanisms of DBS in dystonia and advance precision neuromodulation strategies.

Indexed as

ConnectomeDeep Brain StimulationGlobus PallidusSubthalamic NucleusTorticollisAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcome

Identifiers

PMID40820429
PMCPMC12358681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.