Evidence map›Paper›PMID 40820379›Full record

ArticleEuropean journal of immunology2025

The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses.

Luana Silva, Luís Almeida, Fatima Al-Naimi, Daniele Carvalho Nascimento, Aleksandra Lopez Krol, Luis Eduardo Alves Damasceno, Hakim Echchannaoui, José Carlos Alves-Filho, Luciana Berod, Tim Sparwasser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luana SilvaInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0001-7297-9586
Luís AlmeidaInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-2605-4280
Fatima Al-NaimiInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Daniele Carvalho NascimentoInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Aleksandra Lopez KrolInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0009-0002-3151-9748
Luis Eduardo Alves DamascenoInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0003-2833-9244
Hakim EchchannaouiDepartment of Hematology, Oncology, and Pneumology, University Medical Center (UMC) and University Cancer Center (UCT), Johannes Gutenberg University, Mainz, Germany.
José Carlos Alves-FilhoInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-9918-8714
Luciana BerodResearch Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Tim SparwasserInstitute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

Funding

Deutsche Forschungsgemeinschaft 490846870Deutsche Forschungsgemeinschaft ID318346496Deutsche Forschungsgemeinschaft SFB/CRC1292TP18Deutsche Forschungsgemeinschaft SFB/TRR355/1 TPA04Deutsche Forschungsgemeinschaft TPB08Wilhelm Sander-Stiftung Förderantrags Nr 2023.041.1
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are associated with enhanced tumor progression and reduced therapy response rates. Therefore, overcoming the Treg-mediated immunosuppressive barrier within the tumor to enhance antitumor immune responses is of central interest to advance cancer immunotherapy. To date, no tools exist that can be exploited to dampen Treg function and differentiation in vivo. Here, we show for the first time that the antibiotic thiostrepton exerts a potent inhibitory effect on Tregs. Mechanistically, thiostrepton disrupts Treg differentiation, reduces the expression of Treg activation markers, and inhibits Treg suppressive functions. Accordingly, using an MC38 tumor model, we demonstrate that thiostrepton treatment reduces the number of intratumoral Foxp3

Indexed as

Cell DifferentiationNeoplasmsStreptomycesThiostreptonT-Lymphocytes, RegulatoryAnimalsCell Line, TumorHumansImmunotherapyLymphocyte ActivationMiceThiostreptonimmune responsesimmunotherapyregulatory T cellsT cellstumor immunology

Identifiers

PMID40820379
PMCPMC12358713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.